CSSD Practice Exam 2026 – Complete Study Resource

The toxicity risk associated with vitamin C when taken in megadoses is primarily linked to the formation of kidney stones. High doses of vitamin C can lead to increased oxalate production in the body, which can combine with calcium to form calcium oxalate stones, a common type of kidney stone. This risk is particularly relevant for individuals who may already have a predisposition to kidney stones or who consume a diet high in oxalate-rich foods.

While the other possible risks, such as cardiovascular issues, liver damage, and iron overload, may occur under certain circumstances, they are less directly associated with the high intake of vitamin C. Cardiovascular issues are more commonly related to factors like fats and cholesterol, liver damage can stem from certain medications or alcohol rather than vitamin C, and iron overload typically pertains to individuals with conditions such as hemochromatosis rather than excessive vitamin C intake. Thus, kidney stones remain the most significant toxicity risk specifically linked to vitamin C in megadoses.